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KMID : 0365819690090020167
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Journal of Pusan Medical College
1969 Volume.9 No. 2 p.167 ~ p.169
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The Effects of Phenothiazine Derivatives on K^(+) Permeability of the Rabbit Red Cells
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Abstract
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The author studied the effects of phcnothiazine derivatives cn K# permeability of Me rabbit red cells. The results were as follows.
I) Chlorpromazine, perphenazine and prochlorperazine caused the loss of Ki´ from the erythrocytes in
vitro in the following order;
Chlorpromazine perphenazine> prochlorperazine
2) The K}- loss progressed rapidly for about 60 minutes, however, slowed down thereafter. 3) The K+- loss of erythrocytes increased by the proportion to chlorpromazine concentration.
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